前言

自發(fā)性遺傳模型為研究癲癇全身性發(fā)作，特別是研究癲癇失神發(fā)作提供了基礎。WAG/Rij大鼠用于研究遺傳性癲癇失神發(fā)作，其行為學(xué)改變、EEG表現（表現為棘慢復合板波）以及遺傳特性等方面與人類(lèi)癲癇失神發(fā)作極為相像，已被廣泛用于研究人類(lèi)癲癇失神發(fā)作。

部分造模方法

使用動(dòng)物：大鼠

【造模機制】：

WAG/Rij大鼠來(lái)源于1924年Bacharach培育的遠交系Wistar基因突變大鼠。

【模型特點(diǎn)】：

 目前常用的失神發(fā)作遺傳模型主要為WAG/Rij大鼠，無(wú)論是在清醒或睡眠狀況下，均能記錄到雙側同步、陣發(fā)性的棘波發(fā)放和兩側同步對稱(chēng)的3Hz棘慢波發(fā)放(spike and wave discharges,SWDs)，同時(shí)伴有臨床失神發(fā)作的表現。

【模型評估和應用】：

能顯著(zhù)抑制該模型失神發(fā)作的藥物往往對臨床失神發(fā)作有效，兩者間具有高度相關(guān)性。g－氨基丁酸B1激動(dòng)劑能加重WAG/Rij大鼠模型的SWDs發(fā)放。盡管上述兩種遺傳性失神模型具有自發(fā)失神發(fā)作及SWDs，但因難以大量繁殖，從而使其應用受到限制。

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